Windows 10: How do I fix a HDD Drive with a blue question mark?

My HDD Drive shows a blue question mark next to it. It is not possible for me to access my files that are saved on the drive. When I try to, the error titled "Location is not available" appears. Furthermore the Drive does not appear on the "This PC" tab of File Explorer, unlike my SSD. Any help would be greatly appreciated.Thank You.

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Question mark on HDD

my hdd has a blue question mark symbol on it. i cant access the drive and it is not shown on the disk management

 

Optical drive shows blue question mark and become non responsive

On a HP 650 Probook after migration from a native HDD to a Samsung SSD 850 Pro the DVD drive becomes non functional:
The optical drive works once in Windows 10 and only once, followed by a non recoverable failure state.

In Windows 10 the Optical drive letter shows a blue question mark and the eject button of the optical drive remains non responsive, even when starting up the PC.

Reverting back to the original native HDD (swapping the Samsung SSD to the original HDD), makes the optical drive functional again.

Any idea how to fix the issue of the non recognised Optical drive in Windows 10 when an Samsung SSD is installed on the HP 650 Probook?

Troubleshooting suggestions from HP support were applied without success (e.g. registry key removal of Lower and Upperfilters on registry key
4D36E965-E325-11CE-BFC1-08002BE10318

And several other attempts listed in the following support article: http://support.hp.com/us-en/document/c03370738

 

Internal D drive has a blue question mark.

how to fix blue question mark on internal D drive. I tried running chkdsk /d in command prompt but it says invalid input. I also tried finding the drive in device manager and it shows the drive but it is grayed out. sometimes it is not grayed out and when that happens, the blue question mark goes away but the computer gives me an error when I try to open the drive, then the blue question mark comes back and device manager show it grayed out again.