Windows 10: Is it safe to disable Windows Defender's Real-time protection?

Is it safe to disable Real Time protection in Windows Defender if I ensure to manually scan any downloaded files before using them?

:)

 

Untable to Control Windows Defender Real-time Protection On/Off

Go here >
https://www.tenforums.com/tutorials/3569-turn-off-windows-defender-real-time-protection-windows-10-a.html

and see if one of these options help:

• Option Six: To Enable or Disable Windows Defender Real-time Protection in Group
  Policy
• Option Seven: To Enable or Disable Windows Defender Real-time Protection using
  a REG file

 

Windows Defender "Real Time Protection" will not disable

I cannot disable "Real Time Protection" in windows defender on Win 10 Creator Edition.

I have a 3rd party security software suite from ESET with real time protection so I want to disable the one in Defender. I try and click the slider to "Off" but it immediately bounces back without ever going to off and remains in the "On" position. I have
disabled the antivirus software of windows defender in the registry but the real time defender toggle does not budge.

Anyone else have this issue or know of a solution?

 

Untable to Control Windows Defender Real-time Protection On/Off

Sometimes, we need to turn off Windows Defender Real-time protection. In my experience, this software may cause some error to run Android Emulator such as BigNox. It also slowing down my Android Studio. To disable Windows Defender Real-time protection, I
do these steps:

1. Run Windows PowerShell as administrator
2. execute set-mppreference -DisableRealtimeMonitoring 1

Windows PowerShell

Copyright (C) Microsoft Corporation. All rights reserved.

PS C:\WINDOWS\system32> set-mppreference -DisableRealtimeMonitoring 1

PS C:\WINDOWS\system32>

In Windows registry it will create

Computer\HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows Defender\Real-Time Protection -> DisableRealtimeMonitoring REG_DWORD 1

Tested on Windows 10 Version 10.0.17134 Build 17134

But, during my computer idle, windows always put Real-time protection on. It is so annoying. I want to control Real-time Protection manually.