Windows 10: No USB in Windows, but mouse keyboard ok in BIOS

I just started experiencing this problem after a restart this morning. No mouse, no keyboard, and it seems like none of the USB ports are working when the computer is booted to Windows 10 desktop. I read that this might be because I have fast boot enabled and all the drivers are not loading. Mouse and keyboard work fine in BIOS (Asus board). Even in safe mode, I don't have mouse/keyboard in Windows. I don't have the recovery disk and system restores fail. I did create a Windows USB drive using the media creation tool, but that didn't help either.

I have not tried plugging in a PS2 mouse yet because I don't have one. My data is still all on the hard drive, so should I just order an external hard drive adapter, transfer my files, and reformat?

:)

 

Specific USB Keyboard works in BIOS; but not in OS.

Went on virustotal to check it out, found nothing in regards with the file being dangerous. Here is the result. Antivirus scan for c99a3ad18c079116826734440eac3a957b39cc711b5ff436e9cc773e943186ec at 2016-01-16 21:44:54 UTC - VirusTotal

UPDATE: Error showed up for me, ran my virus scanner and nothing popped up.

 

Specific USB Keyboard works in BIOS; but not in OS.

The device is fully compatible with Windows 10, it simply appears that Windows 10 fails to identify it as the correct type of device.

 

Hi and Welcome to TenForums!

Do the mouse or keyboard light up at all when plugged into the system?

Are they wireless or wired devices?

 

Boot into Setup (Bios) Under the Security tab, if Secure Boot or Fast Boot is enabled, Disable it or Change it to Setup Mode, then go to Integrated Peripherals look for Legacy Boot or Keyboard. If it is disabled, using your Enter and Arrow Key, Enable it. Save and Exit.
If that fails, in the Bios go to the Boot tab, with the USB Flash Drive in, Move USB Device to First Boot Device, Save and Exit. Boot off of your Windows 10 installer, choose your Language and then Repair Your PC.