Windows 10: Unable to click on anything in the Windows 10 UI in order to run programs or even select...

A few days ago an issue began happening on my Windows 10 Gaming Desktop PC. After using it in the morning, I shut it down for a few hours. After turning it back on, it started up very slowly, and once loading I was unable to click on or run anything in the UI taskbar, start menu, notifications tab. I was still able to highlight items but unable to click on them to use anything. I switched out the mouse and keyboard to ones that I knew were working fine. The problem persisted. Yesterday I tried every fix I could find on the internet regarding this, but none worked having limited ability to u

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Unable to run programs in Windows 10

Hi,

Thank you for posting your query on Microsoft Community.

I understand you are unable to run some programs on Windows 10. We will assist you to resolve the issue.

To assist you better, I would like to know what exactly happens when you try to run the programs. Did you get any error message? Which was the previous Operating System installed on the computer?

I suggest you to run the program in Compatibility mode and check if it helps, please follow the below steps:

1) Right click on the Program

2) Click on Properties

3) Click on Compatibility tab

4) Select Run this program in compatibility mode and select the operating system accordingly (Windows 8 or 7) from the drop down list.

Hope the information helps. Let us know if you need further assistance. We will be happy to help.

Thank you.

 

Process running but not starting in Windows 10

Hi,

Thank you for posting your query on Microsoft Community.

I understand that you are unable to run applications on Windows 10. We will assist you to resolve the issue.

This issue may be due to application conflicts.

I suggest you to follow the steps provided below and check if it helps to resolve the explorer issue.

• 
  Press Alt+ctr+Del from Desktop.
  
• 
  Select Task Manager.
  
• 
  Under process tab, locate the apps that are running.
  
• 
  Right Click on the application and select End Task.
  
• 
  Please try accessing the application again and check if you are able to run the application.
  

If the issue persists, I suggest you to run
the program in Compatibility mode, please follow the below steps:

• Right click on the Program
• Click on Properties
• Click on Compatibility tab
• Select Run this program in compatibility mode and select the operating system accordingly from the drop down list.
  

Hope the information helps. Let us know if you need further assistance. We will be happy to help.

Thank you.

 

Default Program does NOT select/set Application

For #1, necessary registry entries have to be added in order for the program to be listed in Default Apps. Regardless, you can right-click a file type that you want to associate with "EditPad", click
Open with... select EditPad from the list and enable the "Always use..." checkbox and click OK.

For #2, As a workaround, click Set defaults by app in the Default Apps window. this option launches the Classic Dfeault Programs UI.

(Note: I've seen this issue happens for local accounts (which was switched back from Microsoft account). Switching to Microsoft account fixes this.
[Fix] Unable to Set Default File Association Using Default Apps in Windows 10)