Windows 10: Unable to use setup.exe files

Whenever i try to use any setup.exe i get shellexecuteex failed code 322122547. How To Fix?Methods I Tried:Running as administrator gives File System Error -1073741819.Typing 'sfc scannow' in cmd.Changing to Windows Default Sounds.What should I do?

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Unable to run .exe format setup files in windows10

unable to install and run .exe format setup files in Windows 10 64bit , couldn't even download Windows Malicious Software Removal Tool . Please do help me...

***Post moved by the moderator to the appropriate forum category.***

 

I changes .exe (Default) files data value, and now I can't open .exe files. Can anyone tell me the normal data value for .exe?

Hello Nilson,

Thank you for posting in Microsoft Community.

I understand that you have changed the values of .exe file extension and now you are unable to open any .exe files. We will help you.

To assist you better, I suggest you to answer the below questions.

• How did you change the values of the .exe file extensions?
• What was the issue to change the values for .exe?
• Is the PC used for testing purpose or you have you changed the values for any developing purpose?

Please post to us with more information to help you better.

 

Some (not all) setup EXE files do not execute.

Many recent EXE application set up files will not run. This presumably started a few days ago, but I then thought it was confined to just one setup EXE (Ultimaker_Cura-4.10.0-amd64.exe). This morning I discovered it's many (but NOT all) of them. The inactive ones seem to be the most recent (4-6 weeks). And if there's an MSI alternative, that does not run either.

As far as I can tell all program EXEs do open correctly. It's just the setup EXEs that have this weird problem.

Examples of setup files that do NOT run:
Everything-1.4.1.1009.x64-Setup.exe
OfficeSetup.exe
iview458_setup.exe
Google_Chrome_(32bit)_v91.0.4472.101.exe
Ultimaker_Cura-4.9.1-amd64.exe

Examples of setup files that DO run:
VLC_Media_Player_(64bit)_v3.0.14.exe
Skype_v8.72.0.94.exe
NotePad_(64bit)_v7.9.5.exe
MediaMonkey_v5.0.0.2338.exe
Everything_(64bit)_v1.4.1.1003.exe
FastStone_Capture_v9.5.exe

Tried many things, including the familiar sfc /scannow, DISM ScanHealth, and various suggestions such as all those here:
Fix: .Exe files not opening in Windows 10

As many do run that was, of course, desperation flying in the face of logic, and none have fixed it.

I'm now pondering the fact that the failures appear to be mainly the more recent files downloaded. Could it be down to a recent Win 10 update I wonder?

This is Win 10 Pro Version 20H2 (OS Build 19042.1110).

- - - Updated - - -

I finally found the cause of the setup EXEs failing.
Tried downloading with Chrome instead of Waterfox. Got a 'Blocked' message. That was the clue to go hunting in the Win 10 Internet security settings. Enabled an obscure option (that perhaps had somehow become disabled) and after download they now execute.