Windows 10: Why can't I click on my Start Menu (sometimes)?

Ok, so disk and file system are ok, and you don't experience the problem in Safe Mode.

But... the task manager in normal mode shows disk activity 100%.

For the moment, we'll assume this latter is the cause of your sluggish responses. (As you experience more, keep an eye on the task man. and confirm that).

(The neatest way to add a screenshot is to use the Insert Image icon to the left of the video icon above your post).

Avast- this is normally a very quiet AV - I've seen others use more resources than they should. So that's a puzzle. Also, I don't recognise Avast Settings Backup. Yes, you can back up settings, but I just ran that, and didn't see that process.

Then there's Skype and Dropbox.
Eclipse is some sort of Java development toolSo I suggest your next step is to do a clean boot, and see if your problems exist then - i.e. try to identify by a process of elimination what is causing bursts of high disk activity.

One further disk test:
Run Crystal DiskMark to check your disk transfer rate and post it's GUI.
And please add your disk type to your system specs.