Windows 10: Booting new drive to Windows as C without disconnecting ?

I cloned a drive SSD to Nvme but I was informed that I must physically disconnect the SSD just to get Windows to boot as C from the Nvme; otherwise Windows will continue to boot as C from the SSD, is there another way to do this without the requirement to physically disconnect the SSD ?

:)

 

Win 10 won't boot, if I disconnect secondary drive(s)

1. Download: Macrium Rescue ISO 6.1.1000 and use: Rufus - Create bootable USB to create a USB Boot.
2. Disconnect Disk 1 from your PC
3. Boot up your PC using the USB in step 1
4. Follow the screen shot to fix Windows Boot

 

Installing Windows on my new C drive

Current Situation: My C Disk is cramming up and I decided to change a new C disk.

Currently my computer storage is composed of an SSD (being my C disk) and an HDD. I bought a new SSD and desire to somehow transfer my current system into the new SSD along with the current environmental variables, user data, both program files folder, and
various other folders instead of installing a brand new system on my new C drive.

Questions I am currently wondering:

1. I noticed the function provided by windows called "Create a system image". Currently my softwares are distributed evenly in my C drive (SSD) and D drive (HDD). I am not changing my HDD, so softwares installed there will not be removed. If I only choose
   to backup my system in my C drive, can I still run my softwares on my HDD after changing a C drive and reinstalling Windows using the generated ISO file?
2. Does this function "create a system image" pack up the environmental variables, registry, along with all other folders in my C drive, or only the minimal system?
3. If I extract the system image ISO into my new C drive, can I somehow "extract" from the ISO file to create a new system in my new drive? If not, is it possible to make my new C drive a windows Boot USB, and directly installing the windows system onto itself?
4. What is your suggested method of making this move?

Thank you for your help!!

 

Wondering about a second hard drive and installing Vista on it and also a ..

Annoying having to go into the bios each time though. And for me not a option unless i run 2 arrays.