Windows 10: Installed new motherboard...problems

Greetings
I had to install a new motherboard in my wife's computer, the system was flakey. The drives were C:, a Sandisk ssd, D: a DVD burner, and E: was a 2TB Seagate HD.

After installing the new motherboard, the drives were C:, a Sandisk ssd, D: was a 2TB Seagate HD., and E: a DVD burner.
Most of her programs were on the Seagate HD, including Microsoft Office 2010. I ahve been trying to re-install Office to no avail. Getting the Microsoft SP1 & 2 of Office as well as the Full version, I tried Add/Repair at the install menu as well as Re-install. Office installer balks at re-install with all 3 packages Saying something about a bad folder name .... which I am currently attempting to install into the new D:Microsoft Office.
Question....Would it be best to change the drive letters of the drives back to the original way they were...or remove Office and re-install?

Thanks for any help.

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The tutorials provided are just a list of troubleshooting steps. Use only the steps which apply to you.

Since none of the troubleshooting steps here worked, I'd suggest you do a Clean install.

John

 

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Everything was fine on 'old' windows, but after I made a clean windows installation, everything goes this way.

Any suggestions?